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Gene: DIO2 (iodothyronine deiodinase 2) Homo sapiens
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Symbol: DIO2
Name: iodothyronine deiodinase 2
Description: Exhibits thyroxine 5'-deiodinase activity and ubiquitin protein ligase binding activity. Involved in thyroid hormone metabolic process. Predicted to localize to the plasma membrane. Implicated in hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; D2; deiodinase, iodothyronine type II; deiodinase, iodothyronine, type II; deiodinase-2; deiodonase-2; DIOII; SelY; thyroxine deiodinase, type II; TXDI2; type 2 DI; type 2 iodothyronine deiodinase; type II iodothyronine deiodinase; type-II 5'-deiodinase; type-II 5'deiodinase
Orthologs:
Mus musculus (house mouse) : Dio2 (deiodinase, iodothyronine, type II)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dio2 (iodothyronine deiodinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio2 (iodothyronine deiodinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO2 (iodothyronine deiodinase 2)
Canis lupus familiaris (dog) : DIO2 (iodothyronine deiodinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio2 (iodothyronine deiodinase 2)
Sus scrofa (pig) : DIO2 (iodothyronine deiodinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381480,197,526 - 80,231,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371480,663,868 - 80,697,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361479,733,622 - 79,748,278 (-)NCBINCBI36hg18NCBI36
Build 341479,733,622 - 79,748,276NCBI
Celera1460,701,940 - 60,716,595 (-)NCBI
Cytogenetic Map14q31.1NCBI
HuRef1460,829,594 - 60,863,130 (-)NCBIHuRef
CHM1_11480,604,355 - 80,637,840 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DIO2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735779
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.