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Gene: DIO2 (iodothyronine deiodinase 2) Homo sapiens
Symbol: DIO2
Name: iodothyronine deiodinase 2
Description: Exhibits thyroxine 5'-deiodinase activity and ubiquitin protein ligase binding activity. Involved in thyroid hormone metabolic process. Predicted to localize to the plasma membrane. Implicated in hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; D2; deiodinase, iodothyronine type II; deiodinase, iodothyronine, type II; deiodinase-2; deiodonase-2; DIOII; SelY; thyroxine deiodinase, type II; TXDI2; type 2 DI; type 2 iodothyronine deiodinase; type II iodothyronine deiodinase; type-II 5'-deiodinase; type-II 5'deiodinase
Mus musculus (house mouse) : Dio2 (deiodinase, iodothyronine, type II)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dio2 (iodothyronine deiodinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio2 (iodothyronine deiodinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO2 (iodothyronine deiodinase 2)
Canis lupus familiaris (dog) : DIO2 (iodothyronine deiodinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio2 (iodothyronine deiodinase 2)
Sus scrofa (pig) : DIO2 (iodothyronine deiodinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381480,197,526 - 80,231,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371480,663,868 - 80,697,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361479,733,622 - 79,748,278 (-)NCBINCBI36hg18NCBI36
Build 341479,733,622 - 79,748,276NCBI
Celera1460,701,940 - 60,716,595 (-)NCBI
Cytogenetic Map14q31.1NCBI
HuRef1460,829,594 - 60,863,130 (-)NCBIHuRef
CHM1_11480,604,355 - 80,637,840 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DIO2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735779
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.