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Gene: CCL3 (C-C motif chemokine ligand 3) Homo sapiens
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Symbol: CCL3
Name: C-C motif chemokine ligand 3
Description: Exhibits several functions, including calcium-dependent protein kinase C activity; chemokine receptor binding activity; and molecular function regulator. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of intracellular signal transduction. Localizes to the cytosol and extracellular space. Implicated in human immunodeficiency virus infectious disease. Biomarker of acute kidney failure; crescentic glomerulonephritis; end stage renal failure; focal segmental glomerulosclerosis; and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-C motif chemokine 3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; LD78 alpha beta; LD78ALPHA; macrophage inflammatory protein 1-alpha; MIP-1-alpha; MIP1A; PAT 464.1; SCYA3; SIS-beta; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; tonsillar lymphocyte LD78 alpha protein
Orthologs:
Mus musculus (house mouse) : Ccl3 (chemokine (C-C motif) ligand 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccl3 (C-C motif chemokine ligand 3)  Alliance
Sus scrofa (pig) : CCL3L1 (chemokine (C-C motif) ligand 3-like 1)
Chlorocebus sabaeus (green monkey) : CCL3 (C-C motif chemokine ligand 3)
more info ...
Related Pseudogenes: CCL3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1736,088,256 - 36,090,169 (-)Ensembl
GRCh381736,088,256 - 36,090,143 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,415,602 - 34,417,506 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,439,715 - 31,441,619 (-)NCBINCBI36hg18NCBI36
Build 341731,439,717 - 31,441,600NCBI
Celera1731,325,155 - 31,327,059 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,600,149 - 30,602,053 (-)NCBIHuRef
CHM1_11734,479,827 - 34,481,731 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CCL3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735784
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.