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Gene: Trpv4 (transient receptor potential cation channel, subfamily V, member 4) Mus musculus
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Symbol: Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
CRRD ID: 735797
Description: Exhibits several functions, including SH2 domain binding activity; calcium channel activity; and osmosensor activity. Involved in several processes, including cellular response to osmotic stress; positive regulation of macromolecule metabolic process; and positive regulation of response to external stimulus. Localizes to adherens junction; cilium; and plasma membrane. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including autopod; brain; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610033B08Rik; MGC150050; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; OTR; OTRPC4; transient receptor potential cation channel subfamily V member 4; transient receptor potential protein 12; Trp; Trp12; trpv4 channel; V; vanilloid receptor-like channel 2; vanilloid receptor-like protein 2; vanilloid receptor-related osmotically-activated channel; VR; VR-OAC; VRL-2; VROAC
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBImm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Trpv4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735797
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.