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Gene: Trpv4 (transient receptor potential cation channel, subfamily V, member 4) Mus musculus
Symbol: Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
CRRD ID: 735797
Description: Exhibits several functions, including SH2 domain binding activity; calcium channel activity; and osmosensor activity. Involved in several processes, including cellular response to osmotic stress; positive regulation of macromolecule metabolic process; and positive regulation of response to external stimulus. Localizes to adherens junction; cilium; and plasma membrane. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including autopod; brain; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610033B08Rik; MGC150050; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; OTR; OTRPC4; transient receptor potential cation channel subfamily V member 4; transient receptor potential protein 12; Trp; Trp12; trpv4 channel; V; vanilloid receptor-like channel 2; vanilloid receptor-like protein 2; vanilloid receptor-related osmotically-activated channel; VR; VR-OAC; VRL-2; VROAC
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBImm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trpv4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735797
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.