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Gene: ENO1 (enolase 1) Homo sapiens
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Symbol: ENO1
Name: enolase 1
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; phosphopyruvate hydratase activity; and protein homodimerization activity. Involved in several processes, including canonical glycolysis; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including the cell cortex region; cell surface; and phosphopyruvate hydratase complex. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2-phospho-D-glycerate hydro-lyase; alpha enolase like 1; alpha-enolase; C-myc promoter-binding protein; c-myc promoter-binding protein 1; c-myc promoter-binding protein-1; ENO1L1; enolase 1, (alpha); enolase 1, alpha; enolase-alpha; epididymis secretory protein Li 17; HEL-S-17; MBP-1; MPB-1; MPB1; MYC promoter-binding protein 1; NNE; non-neural enolase; phosphopyruvate hydratase; plasminogen-binding protein; PPH; tau-crystallin
Orthologs:
Mus musculus (house mouse) : Eno1 (enolase 1, alpha non-neuron)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eno1 (enolase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eno1 (enolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ENO1 (enolase 1)
Canis lupus familiaris (dog) : ENO1 (enolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eno1 (enolase 1)
Sus scrofa (pig) : ENO1 (enolase 1)
more info ...
Related Pseudogenes: ENO1P1   ENO1P2   ENO1P3   ENO1P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818,861,000 - 8,878,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3718,921,059 - 8,939,151 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,843,650 - 8,861,367 (-)NCBINCBI36hg18NCBI36
Build 3418,855,328 - 8,873,046NCBI
Celera18,029,808 - 8,047,527 (-)NCBI
Cytogenetic Map1p36.23NCBI
HuRef18,070,030 - 8,088,151 (-)NCBIHuRef
CHM1_118,910,955 - 8,929,047 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ENO1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735808
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.