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Gene: ENO1 (enolase 1) Homo sapiens
Symbol: ENO1
Name: enolase 1
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; phosphopyruvate hydratase activity; and protein homodimerization activity. Involved in several processes, including canonical glycolysis; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including the cell cortex region; cell surface; and phosphopyruvate hydratase complex. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2-phospho-D-glycerate hydro-lyase; alpha enolase like 1; alpha-enolase; C-myc promoter-binding protein; c-myc promoter-binding protein 1; c-myc promoter-binding protein-1; ENO1L1; enolase 1, (alpha); enolase 1, alpha; enolase-alpha; epididymis secretory protein Li 17; HEL-S-17; MBP-1; MPB-1; MPB1; MYC promoter-binding protein 1; NNE; non-neural enolase; phosphopyruvate hydratase; plasminogen-binding protein; PPH; tau-crystallin
Mus musculus (house mouse) : Eno1 (enolase 1, alpha non-neuron)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eno1 (enolase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eno1 (enolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ENO1 (enolase 1)
Canis lupus familiaris (dog) : ENO1 (enolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eno1 (enolase 1)
Sus scrofa (pig) : ENO1 (enolase 1)
more info ...
Related Pseudogenes: ENO1P1   ENO1P2   ENO1P3   ENO1P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3818,861,000 - 8,878,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3718,921,059 - 8,939,151 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,843,650 - 8,861,367 (-)NCBINCBI36hg18NCBI36
Build 3418,855,328 - 8,873,046NCBI
Celera18,029,808 - 8,047,527 (-)NCBI
Cytogenetic Map1p36.23NCBI
HuRef18,070,030 - 8,088,151 (-)NCBIHuRef
CHM1_118,910,955 - 8,929,047 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ENO1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735808
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.