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Gene: STS (steroid sulfatase) Homo sapiens
Symbol: STS
Name: steroid sulfatase
Description: This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARSC; ARSC1; arylsulfatase C; ASC; ES; estrone sulfatase; SSDD; steroid sulfatase (microsomal), isozyme S; steryl-sulfatase; steryl-sulfate sulfohydrolase; XLI
Mus musculus (house mouse) : Sts (steroid sulfatase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sts (steroid sulfatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sts (steroid sulfatase)
Pan paniscus (bonobo/pygmy chimpanzee) : STS (steroid sulfatase)
Canis lupus familiaris (dog) : STS (steroid sulfatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sts (steroid sulfatase)
Sus scrofa (pig) : STS (steroid sulfatase)
more info ...
Related Pseudogenes: STSP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X7,147,252 - 7,354,643 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X7,065,298 - 7,272,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X7,147,472 - 7,282,682 (+)NCBINCBI36hg18NCBI36
Build 34X6,997,232 - 7,132,416NCBI
CeleraX11,363,616 - 11,498,571 (+)NCBI
Cytogenetic MapXp22.31NCBI
HuRefX4,994,733 - 5,130,162 (+)NCBIHuRef
CHM1_1X7,096,353 - 7,303,668 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on STS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735809
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.