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Gene: UCP1 (uncoupling protein 1) Homo sapiens
Symbol: UCP1
Name: uncoupling protein 1
Description: Exhibits transmembrane transporter activity. Involved in proton transmembrane transport. Localizes to the mitochondrion. Implicated in hypertension and type 2 diabetes mellitus. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: mitochondrial brown fat uncoupling protein 1; SLC25A7; solute carrier family 25 member 7; thermogenin; UCP; UCP 1; uncoupling protein 1 (mitochondrial, proton carrier)
Mus musculus (house mouse) : Ucp1 (uncoupling protein 1 (mitochondrial, proton carrier))  MGI  Alliance
Rattus norvegicus (Norway rat) : Ucp1 (uncoupling protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp1 (uncoupling protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP1 (uncoupling protein 1)
Canis lupus familiaris (dog) : UCP1 (uncoupling protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp1 (uncoupling protein 1)
Sus scrofa (pig) : UCP1 (uncoupling protein 1)
Chlorocebus sabaeus (green monkey) : UCP1 (uncoupling protein 1)
Heterocephalus glaber (naked mole-rat) : Ucp1 (uncoupling protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4140,559,431 - 140,568,961 (-)Ensembl
GRCh384140,555,770 - 140,568,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374141,481,014 - 141,489,989 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364141,700,500 - 141,709,457 (-)NCBINCBI36hg18NCBI36
Build 344141,838,654 - 141,847,612NCBI
Celera4138,811,044 - 138,819,947 (-)NCBI
Cytogenetic Map4q31.1NCBI
HuRef4137,211,503 - 137,220,406 (-)NCBIHuRef
CHM1_14141,458,398 - 141,467,306 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UCP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735821
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.