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Gene: Ucp1 (uncoupling protein 1 (mitochondrial, proton carrier)) Mus musculus
Symbol: Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Description: Exhibits long-chain fatty acid binding activity; oxidative phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including brown fat cell differentiation; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Localizes to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Is expressed in adipose tissue; bone; submandibular gland; testis; and thymus. Orthologous to human UCP1 (uncoupling protein 1); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 2,4-dinitrophenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385626; mitochondrial brown fat uncoupling protein 1; Slc25a7; solute carrier family 25 member 7; thermogenin; Ucp; UCP 1; uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial
Homo sapiens (human) : UCP1 (uncoupling protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ucp1 (uncoupling protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp1 (uncoupling protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP1 (uncoupling protein 1)
Canis lupus familiaris (dog) : UCP1 (uncoupling protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp1 (uncoupling protein 1)
Sus scrofa (pig) : UCP1 (uncoupling protein 1)
Chlorocebus sabaeus (green monkey) : UCP1 (uncoupling protein 1)
Heterocephalus glaber (naked mole-rat) : Ucp1 (uncoupling protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl883,290,352 - 83,298,452 (+)Ensembl
GRCm38883,290,348 - 83,298,456 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37885,814,247 - 85,822,355 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,180,467 - 86,188,157 (+)NCBImm8
Celera887,564,747 - 87,572,801 (+)NCBICelera
Cytogenetic Map8 C2NCBI
cM Map839.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ucp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735822
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.