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Gene: Ucp1 (uncoupling protein 1 (mitochondrial, proton carrier)) Mus musculus
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Symbol: Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Description: Exhibits long-chain fatty acid binding activity; oxidative phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including brown fat cell differentiation; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Localizes to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Is expressed in adipose tissue; bone; submandibular gland; testis; and thymus. Orthologous to human UCP1 (uncoupling protein 1); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 2,4-dinitrophenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385626; mitochondrial brown fat uncoupling protein 1; Slc25a7; solute carrier family 25 member 7; thermogenin; Ucp; UCP 1; uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial
Orthologs:
Homo sapiens (human) : UCP1 (uncoupling protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ucp1 (uncoupling protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp1 (uncoupling protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP1 (uncoupling protein 1)
Canis lupus familiaris (dog) : UCP1 (uncoupling protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp1 (uncoupling protein 1)
Sus scrofa (pig) : UCP1 (uncoupling protein 1)
Chlorocebus sabaeus (green monkey) : UCP1 (uncoupling protein 1)
Heterocephalus glaber (naked mole-rat) : Ucp1 (uncoupling protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl883,290,352 - 83,298,452 (+)Ensembl
GRCm38883,290,348 - 83,298,456 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37885,814,247 - 85,822,355 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,180,467 - 86,188,157 (+)NCBImm8
Celera887,564,747 - 87,572,801 (+)NCBICelera
Cytogenetic Map8 C2NCBI
cM Map839.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ucp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735822
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.