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Gene: GDNF (glial cell derived neurotrophic factor) Homo sapiens
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Symbol: GDNF
Name: glial cell derived neurotrophic factor
Description: Exhibits protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of gene expression; and positive regulation of mesonephros development. Localizes to the Golgi apparatus and extracellular region. Implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Biomarker of acoustic neuroma; autoimmune hypersensitivity disease (multiple); neurodegenerative disease (multiple); pancreatic cancer; and vasculitis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: astrocyte-derived trophic factor; ATF; ATF1; ATF2; glial cell line derived neurotrophic factor; glial cell line-derived neurotrophic factor; HFB1-GDNF; hGDNF; HSCR3
Orthologs:
Mus musculus (house mouse) : Gdnf (glial cell line derived neurotrophic factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gdnf (glial cell derived neurotrophic factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdnf (glial cell derived neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : GDNF (glial cell derived neurotrophic factor)
Canis lupus familiaris (dog) : GDNF (glial cell derived neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdnf (glial cell derived neurotrophic factor)
Sus scrofa (pig) : GDNF (glial cell derived neurotrophic factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38537,812,677 - 37,840,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37537,812,779 - 37,839,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36537,851,510 - 37,875,539 (-)NCBINCBI36hg18NCBI36
Build 34537,851,509 - 37,870,655NCBI
Celera537,699,155 - 37,726,173 (-)NCBI
Cytogenetic Map5p13.2NCBI
HuRef537,765,313 - 37,792,316 (-)NCBIHuRef
CHM1_1537,814,804 - 37,841,806 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GDNF
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735823
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.