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Gene: GDNF (glial cell derived neurotrophic factor) Homo sapiens
Symbol: GDNF
Name: glial cell derived neurotrophic factor
CRRD ID: 735823
Description: Exhibits protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of gene expression; and positive regulation of mesonephros development. Localizes to Golgi apparatus and extracellular region. Implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Biomarker of acoustic neuroma; autoimmune disease (multiple); neurodegenerative disease (multiple); pancreatic cancer; and vasculitis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: astrocyte-derived trophic factor; ATF; ATF1; ATF2; glial cell line derived neurotrophic factor; glial cell line-derived neurotrophic factor; HFB1-GDNF; hGDNF; HSCR3
Mus musculus (house mouse) : Gdnf (glial cell line derived neurotrophic factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gdnf (glial cell derived neurotrophic factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdnf (glial cell derived neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : GDNF (glial cell derived neurotrophic factor)
Canis lupus familiaris (dog) : GDNF (glial cell derived neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdnf (glial cell derived neurotrophic factor)
Sus scrofa (pig) : GDNF (glial cell derived neurotrophic factor)
Chlorocebus sabaeus (African green monkey) : GDNF (glial cell derived neurotrophic factor)
Heterocephalus glaber (naked mole-rat) : Gdnf (glial cell derived neurotrophic factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl537,812,677 - 37,840,041 (-)EnsemblGRCh38hg38GRCh38
GRCh38537,812,677 - 37,840,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37537,812,779 - 37,839,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36537,851,510 - 37,875,539 (-)NCBINCBI36hg18NCBI36
Build 34537,851,509 - 37,870,655NCBI
Celera537,699,155 - 37,726,173 (-)NCBI
Cytogenetic Map5p13.2NCBI
HuRef537,765,313 - 37,792,316 (-)NCBIHuRef
CHM1_1537,814,804 - 37,841,806 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GDNF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735823
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.