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Gene: Adam10 (a disintegrin and metallopeptidase domain 10) Mus musculus
Symbol: Adam10
Name: a disintegrin and metallopeptidase domain 10
Description: Exhibits peptidase activity, acting on L-amino acid peptides; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including cochlea development; proteolysis; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Localizes to several cellular components, including the glutamatergic synapse; pore complex; and postsynaptic density. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Is expressed in several structures, including brain; cranial ganglion; foregut-midgut junction; genitourinary system; and sensory organ. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1700031C13Rik; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; ADAM 10; disintegrin and metalloproteinase domain-containing protein 10; kuz; kuzbanian; kuzbanian protein homolog; MADM; mammalian disintegrin-metalloprotease
Homo sapiens (human) : ADAM10 (ADAM metallopeptidase domain 10)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Adam10 (ADAM metallopeptidase domain 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam10 (ADAM metallopeptidase domain 10)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM10 (ADAM metallopeptidase domain 10)
Canis lupus familiaris (dog) : ADAM10 (ADAM metallopeptidase domain 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam10 (ADAM metallopeptidase domain 10)
Sus scrofa (pig) : ADAM10 (ADAM metallopeptidase domain 10)
Chlorocebus sabaeus (African green monkey) : ADAM10 (ADAM metallopeptidase domain 10)
Heterocephalus glaber (naked mole-rat) : Adam10 (ADAM metallopeptidase domain 10)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl970,678,997 - 70,780,229 (+)Ensembl
GRCm38970,678,944 - 70,780,229 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37970,526,808 - 70,628,036 (+)NCBIGRCm37mm9NCBIm37
MGSCv36970,478,343 - 70,577,515 (+)NCBImm8
Celera967,896,038 - 67,997,081 (+)NCBICelera
Cytogenetic Map9 DNCBI
cM Map939.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Adam10
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735848
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.