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Gene: Ache (acetylcholinesterase) Mus musculus
Symbol: Ache
Name: acetylcholinesterase
Description: Exhibits several functions, including acetylcholinesterase activity; identical protein binding activity; and protein self-association. Involved in several processes, including acetylcholine catabolic process; positive regulation of cold-induced thermogenesis; and receptor metabolic process. Localizes to several cellular components, including basement membrane; cell surface; and neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-pilocarpine; (+)-syringaresinol beta-D-glucoside; (20R)-protopanaxadiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mE1a; mE1b; mE1c; mE1c-long; mE1d; mE1d'; mE1e
Homo sapiens (human) : ACHE (acetylcholinesterase (Cartwright blood group))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ache (acetylcholinesterase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ache (acetylcholinesterase (Cartwright blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : ACHE (acetylcholinesterase (Cartwright blood group))
Canis lupus familiaris (dog) : ACHE (acetylcholinesterase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ache (acetylcholinesterase (Cartwright blood group))
Sus scrofa (pig) : ACHE (acetylcholinesterase)
Chlorocebus sabaeus (African green monkey) : ACHE (acetylcholinesterase (Cartwright blood group))
Heterocephalus glaber (naked mole-rat) : Ache (acetylcholinesterase (Cartwright blood group))
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5137,287,519 - 137,294,466 (+)EnsemblGRCm38mm10GRCm38
GRCm385137,288,247 - 137,294,466 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375137,729,505 - 137,735,691 (+)NCBIGRCm37mm9NCBIm37
MGSCv365137,518,065 - 137,524,251 (+)NCBImm8
Celera5134,271,243 - 134,277,456 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ache
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735879
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.