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Gene: Ache (acetylcholinesterase) Mus musculus
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Symbol: Ache
Name: acetylcholinesterase
Description: Exhibits several functions, including acetylcholinesterase activity; identical protein binding activity; and protein self-association. Involved in several processes, including acetylcholine catabolic process; positive regulation of cold-induced thermogenesis; and receptor metabolic process. Localizes to several cellular components, including basement membrane; cell surface; and neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-pilocarpine; (+)-syringaresinol beta-D-glucoside; (20R)-protopanaxadiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mE1a; mE1b; mE1c; mE1c-long; mE1d; mE1d'; mE1e
Orthologs:
Homo sapiens (human) : ACHE (acetylcholinesterase (Cartwright blood group))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ache (acetylcholinesterase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ache (acetylcholinesterase (Cartwright blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : ACHE (acetylcholinesterase (Cartwright blood group))
Canis lupus familiaris (dog) : ACHE (acetylcholinesterase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ache (acetylcholinesterase (Cartwright blood group))
Sus scrofa (pig) : ACHE (acetylcholinesterase)
Chlorocebus sabaeus (African green monkey) : ACHE (acetylcholinesterase (Cartwright blood group))
Heterocephalus glaber (naked mole-rat) : Ache (acetylcholinesterase (Cartwright blood group))
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5137,287,519 - 137,294,466 (+)EnsemblGRCm38mm10GRCm38
GRCm385137,288,247 - 137,294,466 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375137,729,505 - 137,735,691 (+)NCBIGRCm37mm9NCBIm37
MGSCv365137,518,065 - 137,524,251 (+)NCBImm8
Celera5134,271,243 - 134,277,456 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ache
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735879
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.