Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IL17A (interleukin 17A) Homo sapiens
Analyze
Symbol: IL17A
Name: interleukin 17A
Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CTLA-8; CTLA8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; IL-17; IL-17A; IL17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin-17A
Orthologs:
Mus musculus (house mouse) : Il17a (interleukin 17A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il17a (interleukin 17A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il17a (interleukin 17A)
Pan paniscus (bonobo/pygmy chimpanzee) : IL17A (interleukin 17A)
Canis lupus familiaris (dog) : IL17A (interleukin 17A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il17a (interleukin 17A)
Sus scrofa (pig) : IL17A (interleukin 17A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,186,375 - 52,190,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,051,185 - 52,055,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,159,144 - 52,163,395 (+)NCBINCBI36hg18NCBI36
Build 34652,159,143 - 52,163,395NCBI
Celera653,712,308 - 53,716,559 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,882,254 - 51,886,505 (+)NCBIHuRef
CHM1_1652,053,438 - 52,057,689 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on IL17A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735883
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.