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Gene: B2M (beta-2-microglobulin) Homo sapiens
Symbol: B2M
Name: beta-2-microglobulin
CRRD ID: 735892
Description: Exhibits protein homodimerization activity. Involved in several processes, including amyloid fibril formation; regulation of receptor binding activity; and response to bacterium. Localizes to several cellular components, including Golgi apparatus; HFE-transferrin receptor complex; and MHC class I peptide loading complex. Implicated in arthritis; familial visceral amyloidosis; immunodeficiency 43; and inflammatory bowel disease. Biomarker of several diseases, including artery disease (multiple); encephalomyelitis; measles; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta chain of MHC class I molecules; beta-2 microglobulin; beta-2-microglobin; IMD43
Mus musculus (house mouse) : B2m (beta-2 microglobulin)  MGI  Alliance
Rattus norvegicus (Norway rat) : B2m (beta-2 microglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : B2m (beta-2-microglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : B2M (beta-2-microglobulin)
Canis lupus familiaris (dog) : B2M (beta-2-microglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : B2m (beta-2-microglobulin)
Sus scrofa (pig) : B2M (beta-2-microglobulin)
Chlorocebus sabaeus (African green monkey) : B2M (beta-2-microglobulin)
Heterocephalus glaber (naked mole-rat) : B2m (beta-2-microglobulin)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   LEW-Tg(HLA-B*2705,B2M)33-3Trg   LEW-Tg(HLA-B*2705,B2M)21-4HTrg  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1544,711,487 - 44,718,877 (+)EnsemblGRCh38hg38GRCh38
GRCh381544,711,492 - 44,718,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371545,003,685 - 45,010,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361542,790,977 - 42,797,649 (+)NCBINCBI36hg18NCBI36
Build 341542,790,976 - 42,797,649NCBI
Celera1521,893,442 - 21,900,114 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1521,827,296 - 21,833,968 (+)NCBIHuRef
CHM1_11545,121,781 - 45,128,453 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on B2M
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735892
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.