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Gene: MGMT (O-6-methylguanine-DNA methyltransferase) Homo sapiens
Symbol: MGMT
Name: O-6-methylguanine-DNA methyltransferase
CRRD ID: 735904
Description: Predicted to have methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in negative regulation of apoptotic process and positive regulation of double-strand break repair. Localizes to nucleoplasm. Implicated in several diseases, including cholangiocarcinoma; endocrine gland cancer (multiple); female reproductive organ cancer (multiple); nervous system cancer (multiple); and urinary bladder cancer. Biomarker of breast cancer; pancreatic cancer; and pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 0-6-methylguanine-dna methyltransferase; 6-O-methylguanine-DNA methyltransferase; methylated DNA protein cysteine methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; O6-MGMT
Mus musculus (house mouse) : Mgmt (O-6-methylguanine-DNA methyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mgmt (O-6-methylguanine-DNA methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mgmt (O-6-methylguanine-DNA methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : MGMT (O-6-methylguanine-DNA methyltransferase)
Canis lupus familiaris (dog) : MGMT (O-6-methylguanine-DNA methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mgmt (O-6-methylguanine-DNA methyltransferase)
Sus scrofa (pig) : MGMT (O-6-methylguanine-DNA methyltransferase)
Chlorocebus sabaeus (African green monkey) : MGMT (O-6-methylguanine-DNA methyltransferase)
Heterocephalus glaber (naked mole-rat) : Mgmt (O-6-methylguanine-DNA methyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl10129,467,190 - 129,770,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3810129,467,241 - 129,770,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710131,265,454 - 131,565,783 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610131,155,456 - 131,455,358 (+)NCBINCBI36hg18NCBI36
Build 3410131,155,455 - 131,455,358NCBI
Celera10124,937,282 - 125,237,646 (+)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10124,842,441 - 125,144,551 (+)NCBIHuRef
CHM1_110131,547,578 - 131,848,012 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MGMT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735904
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.