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Gene: Fmr1 (FMRP translational regulator 1) Mus musculus
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Symbol: Fmr1
Name: FMRP translational regulator 1
Description: Exhibits several functions, including RNA binding activity; dynein complex binding activity; and translation repressor activity. Involved in several processes, including positive regulation of cell projection organization; regulation of cellular protein metabolic process; and regulation of mRNA metabolic process. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic ribonucleoprotein granule; and filopodium. Colocalizes with SMN complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Used to study autism spectrum disorder; fragile X syndrome; and fragile X-associated tremor/ataxia syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and premature ovarian failure. Orthologous to human FMR1 (FMRP translational regulator 1); INTERACTS WITH (S)-3,5-dihydroxyphenylglycine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Fmr-1; FMRP; fragile X mental retardation 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; mFmr1p; synaptic functional regulator FMR1
Orthologs:
Homo sapiens (human) : FMR1 (FMRP translational regulator 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fmr1 (FMRP translational regulator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fmr1 (FMRP translational regulator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FMR1 (FMRP translational regulator 1)
Canis lupus familiaris (dog) : FMR1 (FMRP translational regulator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fmr1 (FMRP translational regulator 1)
Sus scrofa (pig) : FMR1 (FMRP translational regulator 1)
Chlorocebus sabaeus (African green monkey) : FMR1 (FMRP translational regulator 1)
Heterocephalus glaber (naked mole-rat) : Fmr1 (FMRP translational regulator 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)EnsemblGRCm38mm10GRCm38
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBImm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBImm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Fmr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735920
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.