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Gene: Fmr1 (FMRP translational regulator 1) Mus musculus
Symbol: Fmr1
Name: FMRP translational regulator 1
Description: Exhibits several functions, including RNA binding activity; dynein complex binding activity; and translation repressor activity. Involved in several processes, including positive regulation of cell projection organization; regulation of cellular protein metabolic process; and regulation of mRNA metabolic process. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic ribonucleoprotein granule; and filopodium. Colocalizes with SMN complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Used to study autism spectrum disorder; fragile X syndrome; and fragile X-associated tremor/ataxia syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and premature ovarian failure. Orthologous to human FMR1 (FMRP translational regulator 1); INTERACTS WITH (S)-3,5-dihydroxyphenylglycine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Fmr-1; FMRP; fragile X mental retardation 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; mFmr1p; synaptic functional regulator FMR1
Homo sapiens (human) : FMR1 (FMRP translational regulator 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fmr1 (FMRP translational regulator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fmr1 (FMRP translational regulator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FMR1 (FMRP translational regulator 1)
Canis lupus familiaris (dog) : FMR1 (FMRP translational regulator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fmr1 (FMRP translational regulator 1)
Sus scrofa (pig) : FMR1 (FMRP translational regulator 1)
Chlorocebus sabaeus (African green monkey) : FMR1 (FMRP translational regulator 1)
Heterocephalus glaber (naked mole-rat) : Fmr1 (FMRP translational regulator 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)EnsemblGRCm38mm10GRCm38
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBImm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBImm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Fmr1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735920
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.