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Gene: C5 (complement C5) Homo sapiens
Symbol: C5
Name: complement C5
Description: Predicted to have chemokine activity. Involved in negative regulation of macrophage chemotaxis; positive regulation of chemokine secretion; and positive regulation of vascular endothelial growth factor production. Localizes to the membrane attack complex. Implicated in several diseases, including asthma; complement component 5 deficiency; liver cirrhosis; neutropenia; and paroxysmal nocturnal hemoglobinuria. Biomarker of adult respiratory distress syndrome; asthma; chronic obstructive pulmonary disease; cystic fibrosis; and factor VIII deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a; C5a anaphylatoxin; C5b; C5D; complement component 5; CPAMD4; ECLZB; FLJ17816; FLJ17822; MGC142298; prepro-C5
Mus musculus (house mouse) : Hc (hemolytic complement)  MGI  Alliance
Rattus norvegicus (Norway rat) : C5 (complement C5)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : C5 (complement C5)
Canis lupus familiaris (dog) : C5 (complement C5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959685 (complement C5)
Sus scrofa (pig) : C5 (complement C5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389120,952,335 - 121,074,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379123,714,613 - 123,812,554 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,754,434 - 122,852,375 (-)NCBINCBI36hg18NCBI36
Build 349120,794,168 - 120,892,108NCBI
Celera994,363,035 - 94,461,011 (-)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,332,095 - 93,430,452 (-)NCBIHuRef
CHM1_19123,861,740 - 123,984,460 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on C5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735934
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.