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Gene: C5 (complement C5) Homo sapiens
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Symbol: C5
Name: complement C5
Description: Predicted to have chemokine activity. Involved in negative regulation of macrophage chemotaxis; positive regulation of chemokine secretion; and positive regulation of vascular endothelial growth factor production. Localizes to the membrane attack complex. Implicated in several diseases, including asthma; complement component 5 deficiency; liver cirrhosis; neutropenia; and paroxysmal nocturnal hemoglobinuria. Biomarker of adult respiratory distress syndrome; asthma; chronic obstructive pulmonary disease; cystic fibrosis; and factor VIII deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a; C5a anaphylatoxin; C5b; C5D; complement component 5; CPAMD4; ECLZB; FLJ17816; FLJ17822; MGC142298; prepro-C5
Orthologs:
Mus musculus (house mouse) : Hc (hemolytic complement)  MGI  Alliance
Rattus norvegicus (Norway rat) : C5 (complement C5)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : C5 (complement C5)
Canis lupus familiaris (dog) : C5 (complement C5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959685 (complement C5)
Sus scrofa (pig) : C5 (complement C5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389120,952,335 - 121,074,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379123,714,613 - 123,812,554 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,754,434 - 122,852,375 (-)NCBINCBI36hg18NCBI36
Build 349120,794,168 - 120,892,108NCBI
Celera994,363,035 - 94,461,011 (-)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,332,095 - 93,430,452 (-)NCBIHuRef
CHM1_19123,861,740 - 123,984,460 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on C5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735934
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.