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Gene: PLCG1 (phospholipase C gamma 1) Homo sapiens
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Symbol: PLCG1
Name: phospholipase C gamma 1
CRRD ID: 735936
Description: Exhibits neurotrophin TRKA receptor binding activity; phosphatidylinositol phospholipase C activity; and protein kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; positive regulation of endothelial cell apoptotic process; and positive regulation of vascular endothelial cell proliferation. Localizes to several cellular components, including COP9 signalosome; lamellipodium; and ruffle. Biomarker of Alzheimer's disease; breast cancer; breast carcinoma; and oral squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; phospholipase C-gamma-1; phospholipase C-II; PLC-148; PLC-gamma-1; PLC-II; PLC1; PLC148; PLCgamma1; triphosphoinositide phosphodiesterase
Orthologs:
Mus musculus (house mouse) : Plcg1 (phospholipase C, gamma 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plcg1 (phospholipase C, gamma 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcg1 (phospholipase C gamma 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCG1 (phospholipase C gamma 1)
Canis lupus familiaris (dog) : PLCG1 (phospholipase C gamma 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcg1 (phospholipase C gamma 1)
Sus scrofa (pig) : PLCG1 (phospholipase C gamma 1)
Chlorocebus sabaeus (African green monkey) : PLCG1 (phospholipase C gamma 1)
Heterocephalus glaber (naked mole-rat) : Plcg1 (phospholipase C gamma 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2041,136,960 - 41,196,801 (+)EnsemblGRCh38hg38GRCh38
GRCh382041,137,519 - 41,177,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372039,766,159 - 39,804,359 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362039,199,575 - 39,237,771 (+)NCBINCBI36hg18NCBI36
Build 342039,199,574 - 39,237,771NCBI
Celera2036,476,730 - 36,514,924 (+)NCBI
Cytogenetic Map20q12NCBI
HuRef2036,504,215 - 36,542,409 (+)NCBIHuRef
CHM1_12039,670,573 - 39,708,755 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PLCG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735936
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.