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Gene: Plcg1 (phospholipase C, gamma 1) Mus musculus
Symbol: Plcg1
Name: phospholipase C, gamma 1
Description: Exhibits glutamate receptor binding activity; phosphatidylinositol phospholipase C activity; and receptor tyrosine kinase binding activity. Involved in T cell receptor signaling pathway; in utero embryonic development; and modulation of chemical synaptic transmission. Localizes to the Schaffer collateral - CA1 synapse; cell-cell junction; and glutamatergic synapse. Predicted to colocalize with the neuron projection. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to human PLCG1 (phospholipase C gamma 1); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; AI894140; Cded; cell differentiation and embryonic development; phosphoinositide phospholipase C-gamma-1; phospholipase C-gamma-1; Plc-1; PLC-gamma-1; Plc-gamma1; Plcg-1
Homo sapiens (human) : PLCG1 (phospholipase C gamma 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plcg1 (phospholipase C, gamma 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcg1 (phospholipase C gamma 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCG1 (phospholipase C gamma 1)
Canis lupus familiaris (dog) : PLCG1 (phospholipase C gamma 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcg1 (phospholipase C gamma 1)
Sus scrofa (pig) : PLCG1 (phospholipase C gamma 1)
Chlorocebus sabaeus (African green monkey) : PLCG1 (phospholipase C gamma 1)
Heterocephalus glaber (naked mole-rat) : Plcg1 (phospholipase C gamma 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2160,731,300 - 160,775,760 (+)Ensembl
GRCm382160,731,310 - 160,775,760 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372160,557,046 - 160,601,496 (+)NCBIGRCm37mm9NCBIm37
MGSCv362160,422,751 - 160,467,201 (+)NCBImm8
Celera2166,663,373 - 166,707,819 (+)NCBICelera
Cytogenetic Map2 H2NCBI
cM Map280.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Plcg1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735937
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.