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Gene: Il2ra (interleukin 2 receptor, alpha chain) Mus musculus
Symbol: Il2ra
Name: interleukin 2 receptor, alpha chain
CRRD ID: 735948
Description: Exhibits interleukin-2 binding activity and interleukin-2 receptor activity. Involved in several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Localizes to external side of plasma membrane. Is expressed in bone marrow. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; endocytosis pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1-chloro-2,4-dinitrobenzene; 1-naphthaleneacetic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD25; I; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; Il2r; interleukin-2 receptor subunit alpha; Ly-4; Ly-43; MGC130561; p55 chain
Homo sapiens (human) : IL2RA (interleukin 2 receptor subunit alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il2ra (interleukin 2 receptor subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2ra (interleukin 2 receptor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2RA (interleukin 2 receptor subunit alpha)
Canis lupus familiaris (dog) : IL2RA (interleukin 2 receptor subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2ra (interleukin 2 receptor subunit alpha)
Sus scrofa (pig) : IL2RA (interleukin 2 receptor subunit alpha)
Chlorocebus sabaeus (African green monkey) : IL2RA (interleukin 2 receptor subunit alpha)
Heterocephalus glaber (naked mole-rat) : Il2ra (interleukin 2 receptor subunit alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39211,647,603 - 11,698,005 (+)NCBI
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIGRCm37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBImm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il2ra
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735948
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.