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Gene: Grem1 (gremlin 1, DAN family BMP antagonist) Mus musculus
Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
Description: Exhibits receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including nephron epithelium morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of transcription, DNA-templated. Localizes to the extracellular space. Colocalizes with the cell surface. Is expressed in several structures, including cranium; embryo mesenchyme; limb; neural ectoderm; and sensory organ. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cktsf1b1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Drm; Grem; gremlin 1; gremlin-1; ld
Homo sapiens (human) : GREM1 (gremlin 1, DAN family BMP antagonist)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grem1 (gremlin 1, DAN family BMP antagonist)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grem1 (gremlin 1, DAN family BMP antagonist)
Pan paniscus (bonobo/pygmy chimpanzee) : GREM1 (gremlin 1, DAN family BMP antagonist)
Canis lupus familiaris (dog) : GREM1 (gremlin 1, DAN family BMP antagonist)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grem1 (gremlin 1, DAN family BMP antagonist)
Sus scrofa (pig) : GREM1 (gremlin 1, DAN family BMP antagonist)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382113,748,674 - 113,759,317 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372113,588,832 - 113,598,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv362113,549,514 - 113,559,485 (-)NCBImm8
Celera2114,881,929 - 114,891,879 (-)NCBICelera
Cytogenetic Map2 E4NCBI
cM Map257.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Grem1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735959
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.