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Gene: Grem1 (gremlin 1, DAN family BMP antagonist) Mus musculus
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Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
Description: Exhibits receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including nephron epithelium morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of transcription, DNA-templated. Localizes to the extracellular space. Colocalizes with the cell surface. Is expressed in several structures, including cranium; embryo mesenchyme; limb; neural ectoderm; and sensory organ. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cktsf1b1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Drm; Grem; gremlin 1; gremlin-1; ld
Orthologs:
Homo sapiens (human) : GREM1 (gremlin 1, DAN family BMP antagonist)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grem1 (gremlin 1, DAN family BMP antagonist)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grem1 (gremlin 1, DAN family BMP antagonist)
Pan paniscus (bonobo/pygmy chimpanzee) : GREM1 (gremlin 1, DAN family BMP antagonist)
Canis lupus familiaris (dog) : GREM1 (gremlin 1, DAN family BMP antagonist)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grem1 (gremlin 1, DAN family BMP antagonist)
Sus scrofa (pig) : GREM1 (gremlin 1, DAN family BMP antagonist)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382113,748,674 - 113,759,317 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372113,588,832 - 113,598,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv362113,549,514 - 113,559,485 (-)NCBImm8
Celera2114,881,929 - 114,891,879 (-)NCBICelera
Cytogenetic Map2 E4NCBI
cM Map257.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Grem1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735959
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-09-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.