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Gene: APOA1 (apolipoprotein A1) Homo sapiens
Symbol: APOA1
Name: apolipoprotein A1
CRRD ID: 735962
Description: Exhibits several functions, including amyloid-beta binding activity; cholesterol binding activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of Rho protein signal transduction. Localizes to endocytic vesicle; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; familial visceral amyloidosis; non-alcoholic steatohepatitis; and systemic lupus erythematosus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; liver disease (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo(a); apo-AI; apoA-I; apolipoprotein A-I; HPALP2; MGC117399
Mus musculus (house mouse) : Apoa1 (apolipoprotein A-I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoa1 (apolipoprotein A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoa1 (apolipoprotein A1)
Pan paniscus (bonobo/pygmy chimpanzee) : APOA1 (apolipoprotein A1)
Canis lupus familiaris (dog) : APOA1 (apolipoprotein A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoa1 (apolipoprotein A1)
Sus scrofa (pig) : APOA1 (apolipoprotein A1)
Chlorocebus sabaeus (African green monkey) : APOA1 (apolipoprotein A1)
Heterocephalus glaber (naked mole-rat) : Apoa1 (apolipoprotein A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11116,835,751 - 116,837,622 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,835,751 - 116,837,950 (-)EnsemblGRCh38hg38GRCh38
GRCh3811116,835,751 - 116,837,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,706,467 - 116,708,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,211,679 - 116,213,548 (-)NCBINCBI36hg18NCBI36
Celera11113,864,272 - 113,866,141 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,638,728 - 112,640,597 (-)NCBIHuRef
CHM1_111116,591,219 - 116,593,418 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on APOA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735962
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.