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Gene: Smo (smoothened, frizzled class receptor) Mus musculus
Symbol: Smo
Name: smoothened, frizzled class receptor
Description: Exhibits drug binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Localizes to 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Predicted to colocalize with Golgi apparatus and caveola. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bent body; bnb; E130215L21Rik; Smoh; smoothened; smoothened homolog
Homo sapiens (human) : SMO (smoothened, frizzled class receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Smo (smoothened, frizzled class receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smo (smoothened, frizzled class receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : SMO (smoothened, frizzled class receptor)
Canis lupus familiaris (dog) : SMO (smoothened, frizzled class receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smo (smoothened, frizzled class receptor)
Sus scrofa (pig) : SMO (smoothened, frizzled class receptor)
Chlorocebus sabaeus (African green monkey) : SMO (smoothened, frizzled class receptor)
Heterocephalus glaber (naked mole-rat) : Smo (smoothened, frizzled class receptor)
more info ...
Related Pseudogenes: Gm4066  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl629,735,503 - 29,761,365 (+)EnsemblGRCm38mm10GRCm38
GRCm38629,735,497 - 29,761,366 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37629,685,497 - 29,711,366 (+)NCBIGRCm37mm9NCBIm37
MGSCv36629,685,513 - 29,711,369 (+)NCBImm8
Celera629,744,569 - 29,772,611 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Smo
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735969
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.