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Gene: IL1RAPL1 (interleukin 1 receptor accessory protein like 1) Homo sapiens
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Symbol: IL1RAPL1
Name: interleukin 1 receptor accessory protein like 1
Description: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IL-1-RAPL-1; IL-1RAPL-1; IL1R8; IL1RAPL; IL1RAPL-1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; interleukin-1 receptor accessory protein-like 1; mental retardation, X-linked 10; mental retardation, X-linked 21; MRX10; MRX21; MRX34; oligophrenin-4; OPHN4; three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X28,587,564 - 29,956,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X28,605,681 - 29,974,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X28,515,480 - 29,884,761 (+)NCBINCBI36hg18NCBI36
Build 34X28,365,215 - 29,734,493NCBI
CeleraX32,732,824 - 34,100,946 (+)NCBI
Cytogenetic MapXp21.3-p21.2NCBI
HuRefX26,346,333 - 27,710,305 (+)NCBIHuRef
CHM1_1X28,636,125 - 30,004,681 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IL1RAPL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735979
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.