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Gene: Atp2a2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2) Mus musculus
Symbol: Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Description: Exhibits several functions, including calcium ion binding activity; calcium transmembrane transporter activity, phosphorylative mechanism; and protein C-terminus binding activity. Involved in several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Localizes to the endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Predicted to colocalize with the intercalated disc. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9530097L16Rik; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; D5Wsu150e; endoplasmic reticulum class 1/2 Ca(2+) ATPase; KIAA4195; mKIAA4195; sarco/endoplasmic reticulum Ca2+-ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; Serca2a; SERCA2a isoform; SERCA2B; SR Ca(2+)-ATPase 2
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5122,453,513 - 122,502,225 (-)Ensembl
GRCm385122,453,513 - 122,502,225 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375122,903,522 - 122,952,234 (-)NCBIGRCm37mm9NCBIm37
MGSCv365122,714,131 - 122,762,512 (-)NCBImm8
Celera5119,532,083 - 119,580,718 (-)NCBICelera
Cytogenetic Map5 FNCBI
cM Map562.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Atp2a2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735992
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.