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Gene: Atp2a2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2) Mus musculus
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Symbol: Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Description: Exhibits several functions, including calcium ion binding activity; calcium transmembrane transporter activity, phosphorylative mechanism; and protein C-terminus binding activity. Involved in several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Localizes to the endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Predicted to colocalize with the intercalated disc. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9530097L16Rik; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; D5Wsu150e; endoplasmic reticulum class 1/2 Ca(2+) ATPase; KIAA4195; mKIAA4195; sarco/endoplasmic reticulum Ca2+-ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; Serca2a; SERCA2a isoform; SERCA2B; SR Ca(2+)-ATPase 2
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5122,453,513 - 122,502,225 (-)Ensembl
GRCm385122,453,513 - 122,502,225 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375122,903,522 - 122,952,234 (-)NCBIGRCm37mm9NCBIm37
MGSCv365122,714,131 - 122,762,512 (-)NCBImm8
Celera5119,532,083 - 119,580,718 (-)NCBICelera
Cytogenetic Map5 FNCBI
cM Map562.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Atp2a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735992
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.