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Gene: MSX2 (msh homeobox 2) Homo sapiens
Symbol: MSX2
Name: msh homeobox 2
CRRD ID: 735997
Description: Exhibits sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to cytosol and nuclear speck. Implicated in craniosynostosis and parietal foramina.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CRS2; FPP; homeobox protein Hox-8; homeobox protein MSX-2; HOX8; MSH; msh homeo box 2; msh homeo box homolog 2 (drosophila); msh homeobox homolog 2; PFM; PFM1
Mus musculus (house mouse) : Msx2 (msh homeobox 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msx2 (msh homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msx2 (msh homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MSX2 (msh homeobox 2)
Canis lupus familiaris (dog) : MSX2 (msh homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msx2 (msh homeobox 2)
Sus scrofa (pig) : MSX2 (msh homeobox 2)
Chlorocebus sabaeus (African green monkey) : MSX2 (msh homeobox 2)
Heterocephalus glaber (naked mole-rat) : Msx2 (msh homeobox 2)
more info ...
Related Pseudogenes: MSX2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5174,724,582 - 174,730,896 (+)EnsemblGRCh38hg38GRCh38
GRCh385174,724,582 - 174,730,896 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375174,151,575 - 174,157,902 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,084,181 - 174,090,508 (+)NCBINCBI36hg18NCBI36
Build 345174,084,207 - 174,090,507NCBI
Celera5170,185,579 - 170,191,910 (+)NCBI
Cytogenetic Map5q35.2NCBI
HuRef5169,246,978 - 169,253,303 (+)NCBIHuRef
CHM1_15173,583,988 - 173,590,298 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MSX2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 735997
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.