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Gene: App (amyloid beta (A4) precursor protein) Mus musculus
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Symbol: App
Name: amyloid beta (A4) precursor protein
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in several processes, including cellular metal ion homeostasis; nervous system development; and regulation of protein metabolic process. Localizes to several cellular components, including the cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Predicted to colocalize with several cellular components, including the cell body; low-density lipoprotein particle; and very-low-density lipoprotein particle. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (S)-nicotine; (Z)-ligustilide; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Abeta; Abpp; Adap; Ag; AL024401; alzheimer disease amyloid A4 protein homolog; amyloid beta A4 protein; amyloidogenic glycoprotein; appican; betaAPP; Cvap; E030013M08Rik; protease nexin II
Orthologs:
Homo sapiens (human) : APP (amyloid beta precursor protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : App (amyloid beta precursor protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : App (amyloid beta precursor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : APP (amyloid beta precursor protein)
Canis lupus familiaris (dog) : APP (amyloid beta precursor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : App (amyloid beta precursor protein)
Sus scrofa (pig) : APP (amyloid beta precursor protein)
Chlorocebus sabaeus (green monkey) : APP (amyloid beta precursor protein)
Heterocephalus glaber (naked mole-rat) : App (amyloid beta precursor protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1684,949,685 - 85,173,766 (-)Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBImm8
Celera1685,161,859 - 85,329,235 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences