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Gene: ISL1 (ISL LIM homeobox 1) Homo sapiens
Symbol: ISL1
Name: ISL LIM homeobox 1
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and enhancer sequence-specific DNA binding activity. Involved in cardiac cell fate determination; positive regulation of transcription by RNA polymerase II; and secondary heart field specification. Predicted to localize to the nuclear chromatin. Implicated in type 1 diabetes mellitus and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: insulin gene enhancer protein ISL-1; Isl-1; ISL1 transcription factor, LIM/homeodomain; isl1 transcription factor, lim/homeodomain 1; islet-1; ISLET1
Mus musculus (house mouse) : Isl1 (ISL1 transcription factor, LIM/homeodomain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Isl1 (ISL LIM homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isl1 (ISL LIM homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISL1 (ISL LIM homeobox 1)
Canis lupus familiaris (dog) : ISL1 (ISL LIM homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isl1 (ISL LIM homeobox 1)
Sus scrofa (pig) : ISL1 (ISL LIM homeobox 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38551,383,448 - 51,394,730 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37550,678,958 - 50,690,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36550,714,715 - 50,726,321 (+)NCBINCBI36hg18NCBI36
Build 34550,715,025 - 50,726,310NCBI
Celera547,625,609 - 47,637,216 (+)NCBI
Cytogenetic Map5q11.1NCBI
HuRef547,642,569 - 47,654,183 (+)NCBIHuRef
CHM1_1550,681,961 - 50,693,557 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ISL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736062
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.