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Gene: PDGFA (platelet derived growth factor subunit A) Homo sapiens
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Symbol: PDGFA
Name: platelet derived growth factor subunit A
Description: Exhibits several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of cell migration; and regulation of phosphate metabolic process. Localizes to the cell surface and extracellular space. Implicated in malignant glioma. Biomarker of Leydig cell tumor; breast cancer; leiomyoma; and prostate adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PDGF A-chain; PDGF subunit A; PDGF-1; PDGF-A; PDGF1; platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A
Orthologs:
Mus musculus (house mouse) : Pdgfa (platelet derived growth factor, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdgfa (platelet derived growth factor subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfa (platelet derived growth factor subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFA (platelet derived growth factor subunit A)
Canis lupus familiaris (dog) : PDGFA (platelet derived growth factor subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfa (platelet derived growth factor subunit A)
Sus scrofa (pig) : PDGFA (platelet derived growth factor subunit A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387497,245 - 520,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377536,895 - 559,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367503,421 - 526,007 (-)NCBINCBI36hg18NCBI36
Celera7505,832 - 559,337 (-)NCBI
Cytogenetic Map7p22.3NCBI
HuRef7455,023 - 477,393 (-)NCBIHuRef
CHM1_17535,640 - 589,379 (-)NCBICHM1_1
CRA_TCAGchr7v27598,080 - 651,496 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PDGFA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736070
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.