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Gene: Tgfbr1 (transforming growth factor, beta receptor I) Mus musculus
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Symbol: Tgfbr1
Name: transforming growth factor, beta receptor I
Description: Exhibits several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Predicted to contribute to growth factor binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of cellular component organization. Localizes to endosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study Loeys-Dietz syndrome; osteoarthritis; and systemic scleroderma. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AL; Alk; Alk-5; ALK5; AU017191; ESK2; Tbet; Tbeta; TbetaR-I; TbetaRI; TGF-beta receptor type I; TGF-beta receptor type-1; TGFR-1; transforming growth factor-beta receptor type I
Orthologs:
Homo sapiens (human) : TGFBR1 (transforming growth factor beta receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tgfbr1 (transforming growth factor, beta receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfbr1 (transforming growth factor beta receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFBR1 (transforming growth factor beta receptor 1)
Canis lupus familiaris (dog) : TGFBR1 (transforming growth factor beta receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfbr1 (transforming growth factor beta receptor 1)
Sus scrofa (pig) : TGFBR1 (transforming growth factor beta receptor 1)
Chlorocebus sabaeus (African green monkey) : TGFBR1 (transforming growth factor beta receptor 1)
Heterocephalus glaber (naked mole-rat) : Tgfbr1 (transforming growth factor beta receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBImm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tgfbr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736083
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.