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Gene: Tgfbr1 (transforming growth factor, beta receptor I) Mus musculus
Symbol: Tgfbr1
Name: transforming growth factor, beta receptor I
Description: Exhibits several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Predicted to contribute to growth factor binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of cellular component organization. Localizes to endosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study Loeys-Dietz syndrome; osteoarthritis; and systemic scleroderma. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AL; Alk; Alk-5; ALK5; AU017191; ESK2; Tbet; Tbeta; TbetaR-I; TbetaRI; TGF-beta receptor type I; TGF-beta receptor type-1; TGFR-1; transforming growth factor-beta receptor type I
Homo sapiens (human) : TGFBR1 (transforming growth factor beta receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tgfbr1 (transforming growth factor, beta receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfbr1 (transforming growth factor beta receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFBR1 (transforming growth factor beta receptor 1)
Canis lupus familiaris (dog) : TGFBR1 (transforming growth factor beta receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfbr1 (transforming growth factor beta receptor 1)
Sus scrofa (pig) : TGFBR1 (transforming growth factor beta receptor 1)
Chlorocebus sabaeus (African green monkey) : TGFBR1 (transforming growth factor beta receptor 1)
Heterocephalus glaber (naked mole-rat) : Tgfbr1 (transforming growth factor beta receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBImm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tgfbr1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736083
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.