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Gene: ASS1 (argininosuccinate synthase 1) Homo sapiens
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Symbol: ASS1
Name: argininosuccinate synthase 1
Description: Exhibits amino acid binding activity; argininosuccinate synthase activity; and identical protein binding activity. Involved in several processes, including alpha-amino acid metabolic process; positive regulation of nitric oxide biosynthetic process; and urea cycle. Localizes to the cytosol. Implicated in citrullinemia; hepatocellular carcinoma; and melanoma. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argininosuccinate synthase; argininosuccinate synthetase 1; arginosuccinate synthetase; ASS; citrulline--aspartate ligase; citrulline-aspartate ligase; CTLN1
Orthologs:
Mus musculus (house mouse) : Ass1 (argininosuccinate synthetase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ass1 (argininosuccinate synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ass1 (argininosuccinate synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ASS1 (argininosuccinate synthase 1)
Canis lupus familiaris (dog) : ASS1 (argininosuccinate synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ass1 (argininosuccinate synthase 1)
Sus scrofa (pig) : ASS1 (argininosuccinate synthase 1)
more info ...
Related Pseudogenes: ASS1P1   ASS1P10   ASS1P11   ASS1P12   ASS1P13   ASS1P14   ASS1P2   ASS1P3   ASS1P4   ASS1P5   ASS1P6   ASS1P7   ASS1P8   ASS1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,444,707 - 130,501,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379133,320,094 - 133,376,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,309,915 - 132,366,482 (+)NCBINCBI36hg18NCBI36
Build 349130,355,212 - 130,406,214NCBI
Celera9103,858,652 - 103,915,182 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9102,805,927 - 102,862,325 (+)NCBIHuRef
CHM1_19133,469,032 - 133,525,591 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ASS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736136
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.