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Gene: DRD4 (dopamine receptor D4) Homo sapiens
Symbol: DRD4
Name: dopamine receptor D4
CRRD ID: 736138
Description: Exhibits several functions, including SH3 domain binding activity; catecholamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; arachidonic acid secretion; and regulation of ion transmembrane transporter activity. Localizes to integral component of plasma membrane. Implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Biomarker of Alzheimer's disease; attention deficit hyperactivity disorder; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor
Mus musculus (house mouse) : Drd4 (dopamine receptor D4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Drd4 (dopamine receptor D4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd4 (dopamine receptor D4)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD4 (dopamine receptor D4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd4 (dopamine receptor D4)
Sus scrofa (pig) : DRD4 (dopamine receptor D4)
Chlorocebus sabaeus (African green monkey) : DRD4 (dopamine receptor D4)
Heterocephalus glaber (naked mole-rat) : Drd4 (dopamine receptor D4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11637,269 - 640,706 (+)EnsemblGRCh38hg38GRCh38
GRCh3811637,269 - 640,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711637,305 - 640,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611627,305 - 630,703 (+)NCBINCBI36hg18NCBI36
Build 3411627,304 - 630,703NCBI
Celera11702,422 - 705,821 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11452,513 - 456,039 (+)NCBIHuRef
CHM1_111636,234 - 639,634 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DRD4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736138
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.