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Gene: IL1RL1 (interleukin 1 receptor like 1) Homo sapiens
Symbol: IL1RL1
Name: interleukin 1 receptor like 1
Description: Predicted to have interleukin-33 binding activity and interleukin-33 receptor activity. Predicted to be involved in interleukin-33-mediated signaling pathway. Localizes to the cytosol; focal adhesion; and plasma membrane. Implicated in asthma and coronary artery disease. Biomarker of asthma; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DER4; FIT-1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL33R; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; interleukin-1 receptor-like 1; MGC32623; ST2; ST2L; ST2V; T1
Mus musculus (house mouse) : Il1rl1 (interleukin 1 receptor-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il1rl1 (interleukin 1 receptor-like 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1rl1 (interleukin 1 receptor like 1)
Canis lupus familiaris (dog) : IL1RL1 (interleukin 1 receptor like 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1rl1 (interleukin 1 receptor like 1)
Sus scrofa (pig) : IL1RL1 (interleukin 1 receptor like 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382102,311,502 - 102,352,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372102,927,962 - 102,968,497 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,294,394 - 102,334,929 (+)NCBINCBI36hg18NCBI36
Build 342102,412,234 - 102,419,698NCBI
Celera297,129,200 - 97,169,642 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef296,692,020 - 96,732,452 (+)NCBIHuRef
CHM1_12102,932,225 - 102,972,834 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL1RL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736158
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.