Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SYK (spleen associated tyrosine kinase) Homo sapiens
Symbol: SYK
Name: spleen associated tyrosine kinase
CRRD ID: 736160
Description: Exhibits phosphotyrosine residue binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cellular metabolic process; and positive regulation of cytokine production. Localizes to T cell receptor complex; cytoplasm; and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp313N1010; FLJ25043; FLJ37489; p72-Syk; spleen tyrosine kinase; tyrosine-protein kinase SYK
Mus musculus (house mouse) : Syk (spleen tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Syk (spleen associated tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syk (spleen associated tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : SYK (spleen associated tyrosine kinase)
Canis lupus familiaris (dog) : SYK (spleen associated tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syk (spleen associated tyrosine kinase)
Sus scrofa (pig) : SYK (spleen associated tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : SYK (spleen associated tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Syk (spleen associated tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl990,801,787 - 90,898,549 (+)EnsemblGRCh38hg38GRCh38
GRCh38990,801,600 - 90,898,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37993,564,012 - 93,660,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36992,603,891 - 92,698,305 (+)NCBINCBI36hg18NCBI36
Build 34990,643,624 - 90,738,036NCBI
Celera963,998,674 - 64,095,487 (+)NCBI
Cytogenetic Map9q22.2NCBI
HuRef963,244,666 - 63,341,118 (+)NCBIHuRef
CHM1_1993,710,434 - 93,807,287 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SYK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736160
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.