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Gene: Capn3 (calpain 3) Mus musculus
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Symbol: Capn3
Name: calpain 3
Description: Exhibits calcium-dependent cysteine-type endopeptidase activity; metal ion binding activity; and molecular adaptor activity. Involved in several processes, including G1 to G0 transition involved in cell differentiation; regulation of transcription, DNA-templated; and sarcomere organization. Localizes to the cytosol; plasma membrane; and protein-containing complex. Used to study autosomal recessive limb-girdle muscular dystrophy type 2A. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Is expressed in several structures, including brain; eye; heart; and musculature. Orthologous to human CAPN3 (calpain 3); INTERACTS WITH bis(2-chloroethyl) sulfide; carbon nanotube; chrysene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323605; calcium-activated neutral proteinase 3; calpain L3; calpain p94; calpain-3; CANP 3; Capa-3; Capa3; Lp82; muscle-specific calcium-activated neutral protease 3; p94; skeletal muscle specific calpain p94
Orthologs:
Homo sapiens (human) : CAPN3 (calpain 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Capn3 (calpain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn3 (calpain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN3 (calpain 3)
Canis lupus familiaris (dog) : CAPN3 (calpain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn3 (calpain 3)
Sus scrofa (pig) : CAPN3 (calpain 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382120,463,593 - 120,504,919 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372120,289,329 - 120,330,655 (+)NCBIGRCm37mm9NCBIm37
MGSCv362120,155,314 - 120,195,940 (+)NCBImm8
Celera2121,617,948 - 121,659,023 (+)NCBICelera
Cytogenetic Map2 E5NCBI
cM Map260.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Capn3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736171
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.