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Gene: PYGB (glycogen phosphorylase B) Homo sapiens
Symbol: PYGB
Name: glycogen phosphorylase B
Description: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: brain; brain glycogen phosphorylase; glycogen phosphorylase, brain form; GPBB; MGC9213; phosphorylase, glycogen
Mus musculus (house mouse) : Pygb (brain glycogen phosphorylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pygb (glycogen phosphorylase B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pygb (glycogen phosphorylase B)
Pan paniscus (bonobo/pygmy chimpanzee) : PYGB (glycogen phosphorylase B)
Canis lupus familiaris (dog) : PYGB (glycogen phosphorylase B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pygb (glycogen phosphorylase B)
Sus scrofa (pig) : PYGB (glycogen phosphorylase B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382025,248,039 - 25,298,012 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372025,228,706 - 25,278,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362025,176,706 - 25,226,648 (+)NCBINCBI36hg18NCBI36
Build 342025,176,705 - 25,226,648NCBI
Celera2025,302,440 - 25,352,386 (+)NCBI
Cytogenetic Map20p11.21NCBI
HuRef2025,186,079 - 25,235,994 (+)NCBIHuRef
CHM1_12025,229,585 - 25,279,528 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PYGB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736182
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.