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Gene: DNASE1 (deoxyribonuclease 1) Homo sapiens
Symbol: DNASE1
Name: deoxyribonuclease 1
Description: Predicted to have DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Localizes to the extracellular exosome. Implicated in systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deoxyribonuclease I; deoxyribonuclease-1; DKFZp686H0155; DNase I, lysosomal; DNL1; Dornase alfa; DRNI; FLJ38093; FLJ44902; human urine deoxyribonuclease I
Mus musculus (house mouse) : Dnase1 (deoxyribonuclease I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnase1 (deoxyribonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnase1 (deoxyribonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DNASE1 (deoxyribonuclease 1)
Canis lupus familiaris (dog) : DNASE1 (deoxyribonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnase1 (deoxyribonuclease 1)
Sus scrofa (pig) : DNASE1 (deoxyribonuclease 1)
Chlorocebus sabaeus (African green monkey) : DNASE1 (deoxyribonuclease 1)
Heterocephalus glaber (naked mole-rat) : Dnase1 (deoxyribonuclease 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl163,611,728 - 3,680,143 (+)Ensembl
GRCh38163,611,737 - 3,665,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37163,661,772 - 3,712,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,642,941 - 3,648,097 (+)NCBINCBI36hg18NCBI36
Build 34163,642,940 - 3,648,096NCBI
Celera163,909,706 - 3,914,804 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef163,671,995 - 3,677,205 (+)NCBIHuRef
CHM1_1163,702,960 - 3,708,116 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNASE1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736197
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.