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Gene: Irs2 (insulin receptor substrate 2) Mus musculus
Symbol: Irs2
Name: insulin receptor substrate 2
CRRD ID: 736205
Description: Exhibits phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of insulin secretion. Localizes to cytosol; plasma membrane; and protein-containing complex. Is expressed in several structures, including brain ventricular layer; hindlimb digit skin; jaw; metanephros; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2); PARTICIPATES IN leptin system pathway; erythropoietin signaling pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4PS; Ir; Irs-2
Homo sapiens (human) : IRS2 (insulin receptor substrate 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irs2 (insulin receptor substrate 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs2 (insulin receptor substrate 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS2 (insulin receptor substrate 2)
Canis lupus familiaris (dog) : IRS2 (insulin receptor substrate 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs2 (insulin receptor substrate 2)
Sus scrofa (pig) : IRS2 (insulin receptor substrate 2)
Chlorocebus sabaeus (African green monkey) : IRS2 (insulin receptor substrate 2)
Heterocephalus glaber (naked mole-rat) : Irs2 (insulin receptor substrate 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl810,984,681 - 11,008,458 (-)EnsemblGRCm38mm10GRCm38
GRCm38810,984,681 - 11,008,929 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37810,986,961 - 11,008,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv36810,986,933 - 11,008,402 (-)NCBImm8
Celera811,160,160 - 11,181,560 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Irs2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736205
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.