Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SHANK2 (SH3 and multiple ankyrin repeat domains 2) Homo sapiens
Analyze
Symbol: SHANK2
Name: SH3 and multiple ankyrin repeat domains 2
Description: Predicted to have GKAP/Homer scaffold activity and ionotropic glutamate receptor binding activity. Involved in several processes, including learning; social behavior; and vocalization behavior. Predicted to colocalize with ionotropic glutamate receptor complex; neurofilament; and postsynaptic membrane. Implicated in autistic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CORTBP1; CTTNBP1; GKAP/SAPAP interacting protein; proline rich synapse associated protein 1; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains protein 2; SHANK; SPANK-3
Orthologs:
Mus musculus (house mouse) : Shank2 (SH3 and multiple ankyrin repeat domains 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shank2 (SH3 and multiple ankyrin repeat domains 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank2 (SH3 and multiple ankyrin repeat domains 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Canis lupus familiaris (dog) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101967789 (SH3 and multiple ankyrin repeat domains protein 2)
Sus scrofa (pig) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Chlorocebus sabaeus (African green monkey) : SHANK2 (SH3 and multiple ankyrin repeat domains 2)
Heterocephalus glaber (naked mole-rat) : Shank2 (SH3 and multiple ankyrin repeat domains 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1170,467,856 - 71,252,577 (-)EnsemblGRCh38hg38GRCh38
GRCh381170,467,854 - 71,252,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371170,313,961 - 70,935,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,991,609 - 70,185,520 (-)NCBINCBI36hg18NCBI36
Build 341170,012,765 - 70,185,520NCBI
Celera1167,575,145 - 68,227,408 (-)NCBI
Cytogenetic Map11q13.3-q13.4NCBI
HuRef1167,062,872 - 67,229,732 (-)NCBIHuRef
HuRef1166,575,130 - 67,004,438 (-)NCBIHuRef
CHM1_11170,197,402 - 70,819,783 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SHANK2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736232
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.