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Gene: HPSE (heparanase) Homo sapiens
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Symbol: HPSE
Name: heparanase
Description: Exhibits heparanase activity; protein dimerization activity; and syndecan binding activity. Involved in several processes, including heparan sulfate proteoglycan catabolic process; positive regulation of osteoblast proliferation; and positive regulation of protein kinase B signaling. Localizes to the lysosome and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endo-glucoronidase; heparanase exon 9&10 deletion; heparanase exon10-deletion; heparanase-1; HPA; HPA1; HPR1; HPSE1; HSE1
Orthologs:
Mus musculus (house mouse) : Hpse (heparanase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hpse (heparanase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hpse (heparanase)
Pan paniscus (bonobo/pygmy chimpanzee) : HPSE (heparanase)
Canis lupus familiaris (dog) : HPSE (heparanase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hpse (heparanase)
Sus scrofa (pig) : HPSE (heparanase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38483,292,461 - 83,335,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37484,213,614 - 84,256,306 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36484,435,492 - 84,475,330 (-)NCBINCBI36hg18NCBI36
Build 34484,570,793 - 84,613,484NCBI
Celera481,506,894 - 81,546,444 (-)NCBI
Cytogenetic Map4q21.23NCBI
HuRef479,956,669 - 79,999,104 (-)NCBIHuRef
CHM1_1484,190,339 - 84,232,732 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HPSE
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736250
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.