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Gene: BRCA2 (BRCA2 DNA repair associated) Homo sapiens
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Symbol: BRCA2
Name: BRCA2 DNA repair associated
Description: Exhibits several functions, including gamma-tubulin binding activity; histone acetyltransferase activity; and protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; histone acetylation; and negative regulation of mammary gland epithelial cell proliferation. Localizes to several cellular components, including the BRCA2-MAGE-D1 complex; centrosome; and nuclear lumen. Implicated in several diseases, including Fanconi anemia (multiple); esophagus squamous cell carcinoma; hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRCA1/BRCA2-containing complex, subunit 2; BRCA2, DNA repair associated; BRCC2; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer susceptibility protein BRCA2; breast cancer type 2 susceptibility protein; BROVCA2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1; fanconi anemia group D1 protein; GLM3; mutant BRCA2; PNCA2; truncated breast and ovarian cancer susceptibility protein 2; truncated breast cancer 2; XRCC11
Orthologs:
Mus musculus (house mouse) : Brca2 (breast cancer 2, early onset)  MGI  Alliance
Rattus norvegicus (Norway rat) : Brca2 (BRCA2, DNA repair associated)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brca2 (BRCA2 DNA repair associated)
Pan paniscus (bonobo/pygmy chimpanzee) : BRCA2 (BRCA2 DNA repair associated)
Canis lupus familiaris (dog) : BRCA2 (BRCA2 DNA repair associated)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brca2 (BRCA2 DNA repair associated)
Sus scrofa (pig) : BRCA2 (BRCA2 DNA repair associated)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381332,315,480 - 32,399,672 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371332,889,617 - 32,973,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361331,787,617 - 31,871,809 (+)NCBINCBI36hg18NCBI36
Build 341331,787,616 - 31,871,805NCBI
Celera1313,956,447 - 14,040,613 (+)NCBI
Cytogenetic Map13q13.1NCBI
HuRef1313,701,252 - 13,785,592 (+)NCBIHuRef
CHM1_11332,857,164 - 32,941,322 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model