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Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Mus musculus
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Description: Exhibits eukaryotic translation initiation factor 2alpha kinase activity and identical protein binding activity. Involved in several processes, including animal organ development; regulation of apoptotic process; and regulation of cellular macromolecule biosynthetic process. Localizes to the endoplasmic reticulum and endoplasmic reticulum membrane. Used to study Wolcott-Rallison syndrome. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is expressed in heart; lens fiber; lens vesicle; and pancreas tip epithelium. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI427929; eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; Pek; Perk; PRKR-like endoplasmic reticulum kinase
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl670,844,515 - 70,905,245 (+)Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBImm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Eif2ak3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736260
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.