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Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Mus musculus
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Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Description: Exhibits eukaryotic translation initiation factor 2alpha kinase activity and identical protein binding activity. Involved in several processes, including animal organ development; regulation of apoptotic process; and regulation of cellular macromolecule biosynthetic process. Localizes to the endoplasmic reticulum and endoplasmic reticulum membrane. Used to study Wolcott-Rallison syndrome. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is expressed in heart; lens fiber; lens vesicle; and pancreas tip epithelium. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI427929; eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; Pek; Perk; PRKR-like endoplasmic reticulum kinase
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl670,844,515 - 70,905,245 (+)Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBImm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Eif2ak3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736260
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.