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Gene: Trim28 (tripartite motif-containing 28) Mus musculus
Symbol: Trim28
Name: tripartite motif-containing 28
CRRD ID: 736266
Description: Exhibits DNA binding activity; protein kinase activity; and transcription coactivator activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including DNA methylation involved in embryo development; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and regulation of nucleobase-containing compound metabolic process. Localizes to RNA polymerase II transcription regulator complex and nuclear lumen. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human TRIM28 (tripartite motif containing 28); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,4-dichlorobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408787; E3 SUMO-protein ligase TRIM28; KAP; KAP-1; KRAB-A-interacting protein; KRI; KRIP-1; MGC102100; MommeD; MommeD9; RING-type E3 ubiquitin transferase TIF1-beta; Tif1; TIF1-beta; Tif1b; Tif1beta; transcription intermediary factor 1-beta; transcriptional intermediary factor 1, beta; tripartite motif protein 28; tripartite motif-containing protein 28
Homo sapiens (human) : TRIM28 (tripartite motif containing 28)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Trim28 (tripartite motif-containing 28)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trim28 (tripartite motif containing 28)
Pan paniscus (bonobo/pygmy chimpanzee) : TRIM28 (tripartite motif containing 28)
Canis lupus familiaris (dog) : TRIM28 (tripartite motif containing 28)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trim28 (tripartite motif containing 28)
Sus scrofa (pig) : TRIM28 (tripartite motif containing 28)
Chlorocebus sabaeus (African green monkey) : TRIM28 (tripartite motif containing 28)
Heterocephalus glaber (naked mole-rat) : Trim28 (tripartite motif containing 28)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39712,758,079 - 12,764,959 (+)NCBI
GRCm38713,024,152 - 13,031,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl712,999,114 - 13,031,035 (+)EnsemblGRCm38mm10GRCm38
MGSCv37713,609,501 - 13,616,381 (+)NCBIGRCm37mm9NCBIm37
MGSCv36711,924,340 - 11,931,208 (+)NCBImm8
Celera710,651,338 - 10,658,223 (+)NCBICelera
Cytogenetic Map7A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trim28
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736266
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.