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Gene: THRA (thyroid hormone receptor alpha) Homo sapiens
Symbol: THRA
Name: thyroid hormone receptor alpha
CRRD ID: 736295
Description: Exhibits several functions, including TBP-class protein binding activity; nuclear receptor activity; and thyroid hormone binding activity. Involved in hormone-mediated signaling pathway; negative regulation of RNA polymerase II transcription preinitiation complex assembly; and transcription by RNA polymerase II. Localizes to cytosol and nucleus. Implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AR7; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog; c-ERBA-1; c-erbA-alpha; CHNG6; EAR-7; EAR7; ERB-T-1; ERBA; ERBA-related 7; ERBA1; MGC000261; MGC43240; NR1A1; nuclear receptor subfamily 1 group A member 1; THRA1; THRA2; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor; V-erbA-related protein 7
Mus musculus (house mouse) : Thra (thyroid hormone receptor alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thra (thyroid hormone receptor alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thra (thyroid hormone receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : THRA (thyroid hormone receptor alpha)
Canis lupus familiaris (dog) : THRA (thyroid hormone receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thra (thyroid hormone receptor alpha)
Sus scrofa (pig) : THRA (thyroid hormone receptor alpha)
Chlorocebus sabaeus (African green monkey) : THRA (thyroid hormone receptor alpha)
Heterocephalus glaber (naked mole-rat) : Thra (thyroid hormone receptor alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1740,058,290 - 40,093,867 (+)EnsemblGRCh38hg38GRCh38
GRCh381740,062,193 - 40,093,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,218,446 - 38,250,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,472,589 - 35,503,646 (+)NCBINCBI36hg18NCBI36
Build 341735,472,588 - 35,499,815NCBI
Celera1734,878,512 - 34,910,230 (+)NCBI
Cytogenetic Map17q21.1NCBI
HuRef1734,012,227 - 34,043,856 (+)NCBIHuRef
CHM1_11738,454,163 - 38,485,823 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on THRA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736295
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.