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Gene: THRA (thyroid hormone receptor alpha) Homo sapiens
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Symbol: THRA
Name: thyroid hormone receptor alpha
Description: Exhibits several functions, including TBP-class protein binding activity; nuclear receptor activity; and thyroid hormone binding activity. Involved in hormone-mediated signaling pathway; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; and transcription by RNA polymerase II. Localizes to the cytosol and nucleus. Implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AR7; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog; c-ERBA-1; c-erbA-alpha; CHNG6; EAR-7; EAR7; ERB-T-1; ERBA; ERBA-related 7; ERBA1; MGC000261; MGC43240; NR1A1; nuclear receptor subfamily 1 group A member 1; THRA1; THRA2; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor; V-erbA-related protein 7
Orthologs:
Mus musculus (house mouse) : Thra (thyroid hormone receptor alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thra (thyroid hormone receptor alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thra (thyroid hormone receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : THRA (thyroid hormone receptor alpha)
Canis lupus familiaris (dog) : THRA (thyroid hormone receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thra (thyroid hormone receptor alpha)
Sus scrofa (pig) : THRA (thyroid hormone receptor alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,062,193 - 40,093,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,218,446 - 38,250,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,472,589 - 35,503,646 (+)NCBINCBI36hg18NCBI36
Build 341735,472,588 - 35,499,815NCBI
Celera1734,878,512 - 34,910,230 (+)NCBI
Cytogenetic Map17q21.1NCBI
HuRef1734,012,227 - 34,043,856 (+)NCBIHuRef
CHM1_11738,454,163 - 38,485,823 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on THRA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736295
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.