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Gene: CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) Homo sapiens
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Symbol: CNP
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Description: Predicted to have 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Localizes to several cellular components, including the extracellular space; microtubule; and nucleoplasm. Implicated in multiple sclerosis and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome; INTERACTS WITH 2-hydroxypropanoic acid; all-trans-retinoic acid; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2', 3' cyclic nucleotide 3' phosphohydrolase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP1; CNPase
Orthologs:
Mus musculus (house mouse) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)
Pan paniscus (bonobo/pygmy chimpanzee) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
Canis lupus familiaris (dog) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)
Sus scrofa (pig) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,118,737 - 40,129,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBINCBI36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CNP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736298
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.