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Gene: GPNMB (glycoprotein nmb) Homo sapiens
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Symbol: GPNMB
Name: glycoprotein nmb
Description: Exhibits heparin binding activity; receptor ligand activity; and syndecan binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; and positive regulation of protein autophosphorylation. Localizes to the integral component of membrane. Implicated in primary cutaneous amyloidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glycoprotein (transmembrane) nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; hematopoietic growth factor inducible neurokinin-1; hematopoietic growth factor inducible neurokinin-1 type; HGFIN; NMB; osteoactivin; PLCA3; transmembrane glycoprotein HGFIN; transmembrane glycoprotein NMB
Orthologs:
Mus musculus (house mouse) : Gpnmb (glycoprotein (transmembrane) nmb)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpnmb (glycoprotein nmb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpnmb (glycoprotein nmb)
Pan paniscus (bonobo/pygmy chimpanzee) : GPNMB (glycoprotein nmb)
Canis lupus familiaris (dog) : GPNMB (glycoprotein nmb)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpnmb (glycoprotein nmb)
Sus scrofa (pig) : GPNMB (glycoprotein nmb)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38723,246,766 - 23,275,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37723,286,305 - 23,314,729 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36723,252,841 - 23,281,254 (+)NCBINCBI36hg18NCBI36
Build 34723,059,555 - 23,087,968NCBI
Celera723,272,604 - 23,301,017 (+)NCBI
Cytogenetic Map7p15.3NCBI
HuRef723,168,651 - 23,197,066 (+)NCBIHuRef
CHM1_1723,286,943 - 23,315,354 (+)NCBICHM1_1
CRA_TCAGchr7v2723,338,195 - 23,366,606 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GPNMB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736300
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.