Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: GPNMB (glycoprotein nmb) Homo sapiens
Symbol: GPNMB
Name: glycoprotein nmb
Description: Exhibits heparin binding activity; receptor ligand activity; and syndecan binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; and positive regulation of protein autophosphorylation. Localizes to the integral component of membrane. Implicated in primary cutaneous amyloidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glycoprotein (transmembrane) nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; hematopoietic growth factor inducible neurokinin-1; hematopoietic growth factor inducible neurokinin-1 type; HGFIN; NMB; osteoactivin; PLCA3; transmembrane glycoprotein HGFIN; transmembrane glycoprotein NMB
Mus musculus (house mouse) : Gpnmb (glycoprotein (transmembrane) nmb)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpnmb (glycoprotein nmb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpnmb (glycoprotein nmb)
Pan paniscus (bonobo/pygmy chimpanzee) : GPNMB (glycoprotein nmb)
Canis lupus familiaris (dog) : GPNMB (glycoprotein nmb)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpnmb (glycoprotein nmb)
Sus scrofa (pig) : GPNMB (glycoprotein nmb)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38723,246,766 - 23,275,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37723,286,305 - 23,314,729 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36723,252,841 - 23,281,254 (+)NCBINCBI36hg18NCBI36
Build 34723,059,555 - 23,087,968NCBI
Celera723,272,604 - 23,301,017 (+)NCBI
Cytogenetic Map7p15.3NCBI
HuRef723,168,651 - 23,197,066 (+)NCBIHuRef
CHM1_1723,286,943 - 23,315,354 (+)NCBICHM1_1
CRA_TCAGchr7v2723,338,195 - 23,366,606 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GPNMB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736300
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.