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Gene: LGALS3 (galectin 3) Homo sapiens
Symbol: LGALS3
Name: galectin 3
CRRD ID: 736304
Description: Exhibits several functions, including IgE binding activity; chemoattractant activity; and laminin binding activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of mononuclear cell migration; and regulation of apoptotic process. Localizes to several cellular components, including immunological synapse; mitochondrial inner membrane; and other organism cell. Implicated in asthma. Biomarker of aortic valve stenosis and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 35 kDa lectin; advanced glycation end-product receptor 3; carbohydrate-binding protein 35; CBP35; GAL3; galactose-specific lectin 3; GALBP; galectin-3; GALIG; IgE-binding protein; L31; laminin-binding protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside binding soluble 3; lectin, galactoside-binding, soluble, 3; LGALS2; MAC-2 antigen; MAC2
Mus musculus (house mouse) : Lgals3 (lectin, galactose binding, soluble 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lgals3 (galectin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lgals3 (galectin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LGALS3 (galectin 3)
Canis lupus familiaris (dog) : LGALS3 (galectin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lgals3 (galectin 3)
Sus scrofa (pig) : LGALS3 (galectin 3)
Chlorocebus sabaeus (African green monkey) : LGALS3 (galectin 3)
Heterocephalus glaber (naked mole-rat) : Lgals3 (galectin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GeneID 3958 had the official symbol LGALS2 and was identified as the human homolog of mouse Mac-2 (macrophage galactose-specific lectin) in M35368.1 and PMID: 2402511. The official symbol for this gene is now LGALS3. [30 Mar 2010]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1455,124,110 - 55,145,423 (+)EnsemblGRCh38hg38GRCh38
GRCh381455,129,252 - 55,145,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371455,595,935 - 55,612,148 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,665,625 - 54,681,901 (+)NCBINCBI36hg18NCBI36
Build 341454,665,757 - 54,681,881NCBI
Celera1435,645,428 - 35,661,641 (+)NCBI
Cytogenetic Map14q22.3NCBI
HuRef1435,758,537 - 35,774,750 (+)NCBIHuRef
CHM1_11455,534,573 - 55,550,756 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LGALS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736304
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.