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Gene: EGLN2 (egl-9 family hypoxia inducible factor 2) Homo sapiens
Symbol: EGLN2
Name: egl-9 family hypoxia inducible factor 2
CRRD ID: 736328
Description: Exhibits ferrous iron binding activity; oxygen sensor activity; and peptidyl-proline 4-dioxygenase activity. Involved in several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and positive regulation of protein catabolic process. Localizes to nucleoplasm. Implicated in renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp434E026; egl nine homolog 2; egl-9 family hypoxia-inducible factor 2; EIT-6; EIT6; estrogen-induced tag 6; FLJ95603; HIF prolyl hydroxylase 1; HIF-PH1; HIF-prolyl hydroxylase 1; HIFPH1; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 1; PHD1; prolyl hydroxylase domain-containing protein 1; prolyl hydroxylase EGLN2
Mus musculus (house mouse) : Egln2 (egl-9 family hypoxia-inducible factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egln2 (egl-9 family hypoxia-inducible factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln2 (egl-9 family hypoxia inducible factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Canis lupus familiaris (dog) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln2 (egl-9 family hypoxia inducible factor 2)
Sus scrofa (pig) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Chlorocebus sabaeus (African green monkey) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Heterocephalus glaber (naked mole-rat) : Egln2 (egl-9 family hypoxia inducible factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1940,798,996 - 40,808,434 (+)EnsemblGRCh38hg38GRCh38
GRCh381940,799,191 - 40,808,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,305,048 - 41,314,346 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,996,888 - 46,006,177 (+)NCBINCBI36hg18NCBI36
Build 341945,996,984 - 46,006,176NCBI
Celera1938,105,456 - 38,114,745 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,738,282 - 37,747,581 (+)NCBIHuRef
CHM1_11941,304,720 - 41,314,010 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EGLN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736328
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.