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Gene: ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) Homo sapiens
Symbol: ROS1
Name: ROS proto-oncogene 1, receptor tyrosine kinase
Description: Exhibits protein phosphatase binding activity and protein tyrosine kinase activity. Involved in protein phosphorylation; regulation of TOR signaling; and regulation of cell growth. Predicted to localize to the integral component of plasma membrane and receptor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; MCF3; proto-oncogene c-Ros; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; ROS; ROS proto-oncogene 1 , receptor tyrosine kinase; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Mus musculus (house mouse) : Ros1 (Ros1 proto-oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ros1 (ROS proto-oncogene 1 , receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ros1 (ROS proto-oncogene 1, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)
Canis lupus familiaris (dog) : ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ros1 (ROS proto-oncogene 1, receptor tyrosine kinase)
Sus scrofa (pig) : ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386117,287,918 - 117,426,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376117,609,530 - 117,747,018 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366117,716,223 - 117,853,711 (-)NCBINCBI36hg18NCBI36
Build 346117,716,222 - 117,853,711NCBI
Celera6118,352,446 - 118,489,916 (-)NCBI
Cytogenetic Map6q22.1NCBI
HuRef6115,189,890 - 115,327,310 (-)NCBIHuRef
CHM1_16117,873,670 - 118,011,105 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ROS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736329
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.