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Gene: PSMA6 (proteasome 20S subunit alpha 6) Homo sapiens
Symbol: PSMA6
Name: proteasome 20S subunit alpha 6
Description: Exhibits NF-kappaB binding activity and RNA binding activity. Involved in positive regulation of NF-kappaB transcription factor activity and proteolysis involved in cellular protein catabolic process. Localizes to nucleoplasm; polysome; and proteasome core complex, alpha-subunit complex. Implicated in myocardial infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 27 kDa prosomal protein; IOTA; macropain iota chain; macropain subunit iota; MGC22756; MGC2333; MGC23846; multicatalytic endopeptidase complex iota chain; p27K; PROS-27; PROS27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type 6; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha type-6; proteasome subunit alpha1; proteasome subunit iota; testicular secretory protein Li 44
Mus musculus (house mouse) : Psma6 (proteasome subunit alpha 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Psma6 (proteasome 20S subunit alpha 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psma6 (proteasome 20S subunit alpha 6)
Pan paniscus (bonobo/pygmy chimpanzee) : PSMA6 (proteasome 20S subunit alpha 6)
Canis lupus familiaris (dog) : PSMA6 (proteasome 20S subunit alpha 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psma6 (proteasome 20S subunit alpha 6)
Sus scrofa (pig) : PSMA6 (proteasome 20S subunit alpha 6)
Chlorocebus sabaeus (African green monkey) : PSMA6 (proteasome 20S subunit alpha 6)
Heterocephalus glaber (naked mole-rat) : Psma6 (proteasome 20S subunit alpha 6)
more info ...
Related Pseudogenes: PSMA6P1   PSMA6P2   PSMA6P3   PSMA6P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1435,278,633 - 35,317,493 (+)EnsemblGRCh38hg38GRCh38
GRCh381435,278,558 - 35,317,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371435,747,811 - 35,786,680 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,831,325 - 34,856,431 (+)NCBINCBI36hg18NCBI36
Build 341434,831,324 - 34,856,429NCBI
Celera1415,625,404 - 15,650,528 (+)NCBI
Cytogenetic Map14q13.2NCBI
HuRef1415,875,787 - 15,900,913 (+)NCBIHuRef
CHM1_11435,747,501 - 35,786,435 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PSMA6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736338
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.