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Gene: PRKCZ (protein kinase C zeta) Homo sapiens
Symbol: PRKCZ
Name: protein kinase C zeta
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; and regulation of protein phosphorylation. Localizes to several cellular components, including the cell-cell junction; cytosol; and vesicle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: nPKC-zeta; PKC-ZETA; PKC2; protein kinase C zeta type
Mus musculus (house mouse) : Prkcz (protein kinase C, zeta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkcz (protein kinase C, zeta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkcz (protein kinase C zeta)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCZ (protein kinase C zeta)
Canis lupus familiaris (dog) : PRKCZ (protein kinase C zeta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkcz (protein kinase C zeta)
Sus scrofa (pig) : PRKCZ (protein kinase C zeta)
Chlorocebus sabaeus (African green monkey) : PRKCZ (protein kinase C zeta)
Heterocephalus glaber (naked mole-rat) : Prkcz (protein kinase C zeta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12,050,411 - 2,185,395 (+)EnsemblGRCh38hg38GRCh38
GRCh3812,050,411 - 2,185,399 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711,981,909 - 2,116,834 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,971,769 - 2,106,694 (+)NCBINCBI36hg18NCBI36
Build 3412,014,070 - 2,148,996NCBI
Celera1476,373 - 611,123 (-)NCBI
Cytogenetic Map1p36.33NCBI
HuRef11,259,190 - 1,392,660 (+)NCBIHuRef
CHM1_111,969,035 - 2,101,756 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKCZ
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736361
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.