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Gene: REN (renin) Homo sapiens
Symbol: REN
Name: renin
Description: Exhibits aspartic-type endopeptidase activity and signaling receptor binding activity. Involved in angiotensin maturation; kidney development; and regulation of MAPK cascade. Localizes to the apical part of cell and extracellular space. Implicated in familial juvenile hyperuricemic nephropathy; hypertension; and portal hypertension. Biomarker of atrial fibrillation; chronic fatigue syndrome; myocardial infarction; and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: angiotensin-forming enzyme; angiotensinogenase; FLJ10761; HNFJ2; renin 1; renin precursor, renal
Mus musculus (house mouse) : Ren1 (renin 1 structural)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ren (renin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ren (renin)
Pan paniscus (bonobo/pygmy chimpanzee) : REN (renin)
Canis lupus familiaris (dog) : REN (renin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ren (renin)
Sus scrofa (pig) : REN (renin)
Chlorocebus sabaeus (green monkey) : REN (renin)
Heterocephalus glaber (naked mole-rat) : Ren (renin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1204,154,819 - 204,190,324 (-)Ensembl
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371204,123,944 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures
Clinical Variants

Additional Information

External Database Links
More on REN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 736366
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.